RECOMBINANT HUMAN BONE MORPHOGENIC PROTEIN-2 (rhBMP-2) USE IN MAXILLOFACIAL SURGERY
نویسنده
چکیده
Surgeons can now control osteogenesis through local application of BMP-2. BMP’s are osteoinductive proteins that are located in bone matrix and are responsible for embryonic skeletal formation and bone healing. Marshal Urist first coined the term “bone morphogenic protein” over 40 years ago. Recombinant human BMP-2 is an osteoinductive growth factor that has the potential to make autogenous bone grafting unnecessary. By demonstrating the capabilities of demineralized bone matrix to induce ectopic bone formation in a rat muscle pouch. Urist introduced the concept that growth factors can induce bone formation independent of a bone tissue environment.
منابع مشابه
Bone morphogenetic protein for sinus augmentation.
Bone morphogenic proteins (BMP) are members of the family of transforming growth factors. Fifteen different BMP have been identified, all with varying degrees of cellular activity, including cartilageor bone-inductive properties. Two recombinant proteins are available: recombinant human bone morphogenetic protein (rhBMP)-2 and rhBMP-7. These products have been investigated as alternatives to au...
متن کاملRecombinant Human Bone Morphogenetic Protein-2 in Development and Progression of Oral Squamous Cell Carcinoma.
Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor-β superfamily, regulate many cellular activities including cell migration, differentiation, adhesion, proliferation and apoptosis. Use of recombinant human bone morphogenic protein?2 (rhBMP?2) in oral and maxillofacial surgery has seen a tremendous increase. Due to its role in many cellular pathways, the influence o...
متن کاملRisk of Cancer After Lumbar Fusion Surgery With Recombinant Human Bone Morphogenic Protein-2 (rh-BMP-2)
STUDY DESIGN Retrospective cohort study among Medicare beneficiaries with lumbar spinal fusion surgery. OBJECTIVE To determine the risk of subsequent cancer among patients who received recombinant human bone morphogenic protein (rhBMP) at surgery compared with those who did not. SUMMARY OF BACKGROUND DATA rhBMP is commonly used to promote bone union after spinal surgery. BMP receptors are p...
متن کاملOff-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for reconstruction of mandibular bone defects in humans.
PURPOSE The off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the treatment of mandibular bone defects was evaluated in 5 patients. The rhBMP-2 was used as an alternative to autogenous bone grafting. PATIENTS AND METHODS A total of 5 patients had mandibular defects reconstructed with rhBMP-2, 1.5 mg/mL, soaked collagen sponges alone or in combination with bone marr...
متن کاملThe use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillofacial trauma
In recent years, recombinant human bone morphogenetic protein-2 (rhBMP-2) has been introduced as a therapeutic option in the treatment of several congenital and acquired craniofacial defects. Although there have been promising clinical results, the international literature still lacks complete guidelines, including limits and indications for the use of rhBMP-2. The possible indications for rhBM...
متن کامل